Effect of squalane on hexachlorobenzene (HCB) concentrations in tissues of mice
Titel:
Effect of squalane on hexachlorobenzene (HCB) concentrations in tissues of mice
Auteur:
Richter, E. Schafer, S. G.
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 17 (1982) nr. 3 pagina's 195-203
Jaar:
1982
Inhoud:
Female mice were given 100 mg HCB/kg body weight i.p. and fed diets containing 0, 2.5, 5.0, and 7.5% of squalane. After 3 weeks samples of livar, blood and abdominal fat ware analysed for HCB as well as for squalane. HCB concentrations were significantly lowered as comoared to controls in all tissues and at all dietary concentrations of squalane to a maximum of about 36% in fat, 44% in liver and 47% in blood. The effect of squalane upon HCB concentrations was strongly dose depedent in abdominal fat. In contrast, no significant differences were seen with liver and blood between animals fed 5.0 or 7.5% of squalane. Squalane was detected in considerable amounts in the livers (50-100 ppm) but r.ct in abdominal fat (<1 ppm) of mice fed squalane.
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