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Details for article 4 of 9 found articles
| Title: |
Inhibition of pancreatic carboxypeptidase A: A possible mechanism of interaction between penicillic acid and ochratoxin A |
| Author: |
Parker, Roger W. Phillips, Timothy D. Kubena, Leon F. Russell, Leon H. Heidelbaugh, Norman D. |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 17 (1982) nr. 2 pages 77-91 |
| Year: |
1982 |
| Contents: |
Penicillic acid and ochratoxin A are environmentally important toxic fungal metabolites (mycotoxins) that are synergistic in combination. The effects of penicillic acid on the pancreatic enzyme, :arboxypeptidase A were investigated in vitro and in vivo. A broad range of inhibition in vitro of the enzyme by PA was demonstrated with a half-maximal inhibitory concentration equal to 1.1 x 10-4M PA. Inhibition of carboxypeptidase A was time and temperature dependent, and resulted in decreased conversion of parent ochratoxin A to the non-toxic metabolite, ochratoxin alpha. Studies in vivo demonstrated a penicillic acid-dependent inhibition of pancreatic carboxypeptidase A activity in the mouse and the chicken following multiple oral exposure. It is postulated that the mode of toxic interaction of the two mycotoxins may be due, in part, to impaired detoxification of ochratoxin A through peni-cillic acid depletion of carboxypeptidase A activity. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 4 of 9 found articles
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