Effects of cadmium, zinc, copper and manganese on hepatic parenchymal cell gluconeogenesis
Titel:
Effects of cadmium, zinc, copper and manganese on hepatic parenchymal cell gluconeogenesis
Auteur:
Tolbert, Margaret E. M. Kamalu, Johnson A. Draper, Garnette D.
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 16 (1981) nr. 5 pagina's 575-585
Jaar:
1981
Inhoud:
The effects of divalent cations on gluconeogenesis in enzy-matically isolated rat hepatic parenchymal cells were examined. Cadmium, zinc and copper decreased glucose production from lactate (10 mM). However, manganese at 0.05 to 1.0 mM levels stimulated gluconeogenesis by the cells and reduced the effects of the Cd+2, Zn+2 and Cu+2 on gluconeogenesis. The results indicate that under these in vitro conditions the cations altered an aspect of hepatic function—gluconeogenesis from lactate.