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| Titel: |
Antimicrobial effects of clofibrate on the wheat pathogen Fusarium culmorum |
| Auteur: |
Madhosingh, Clarence Orr, Winson |
| Verschenen in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paginering: | Jaargang 16 (1981) nr. 5 pagina's 587-604 |
| Jaar: |
1981 |
| Inhoud: |
The biological effects of clofibrate (ethyl p-chlorophenoxy-isobutyric acid) on the growth and metabolism of the soil-borne wheat pathogen Fusarium culmorum, were examined. In mid log phase (16 hr) cultures both phenylalanine uptake and secondary spore production were stimulated at 0.1 μM concentration; the net sterol content was reduced 50% at 0.35 μM; oxygen uptake was stimulated at 0.1 mM; growth was inhibited 50% at 0.1 mM concentration. Both phenylalanine and oxygen uptake were inhibited at 1.0 mM and pyruvate dehydrogenase activity was reduced 50% at 50 mM concentration of clofibrate. The data indicate that clofibrate affects a number of biological and enzyme systems. The inhibitory effect on the growth of the pathogen suggest a potential use of hypolipidemic agents like clofibrate as an antifungal agent for seed protection. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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