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Details for article 21 of 29 found articles
| Title: |
Organophosphate pesticide inhibition of cholinesterase in laboratory animals and man and effects of oxine reactivators |
| Author: |
Shellenberger, T. E. |
| Appeared in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paging: | Volume 15 (1980) nr. 6 pages 795-822 |
| Year: |
1980 |
| Contents: |
The responses of rabbit whole blood cholinesterase following intervaneous infusion or percutaneous application of dialkylphosphate inhibitors and injection of oxime enzyme reastivators. The experiments were conducted to determine the structure-activity relationships of the inhibitors and the reactivators, establish the mechanisms of enzyme inhibition, and investigate other factors affecting the toxicity of organophosphate esters including percutaneous absorption and conversion of dithioates to the more reactive respective ozones. Intravenous infusion of dialkylphosphate esters produced dose and time dependent inhibition, followed by a spontaneous, but incomplete recovery . The lack of complete recovery was not totally due to the “aging”; phenomona as measurable enzyme reactivation could be induced subsequent to the spontaneous recovery. The need for revision of the enzyme inhibition model is discussed. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 21 of 29 found articles
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