Neurotoxicity of halogenated o-phenyl o-alkyl alkylphosphonothioates
Titel:
Neurotoxicity of halogenated o-phenyl o-alkyl alkylphosphonothioates
Auteur:
Francis, B. M. Hansen, L. G. Metcalf, R. L.
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 15 (1980) nr. 4 pagina's 313-331
Jaar:
1980
Inhoud:
Twenty-seven halogenated organophosphorus esters were tested for neurotoxicity in adult hens. Fourteen compounds were overtly neurotoxic, including eight of eleven methylphosphonothioates, three of seven ethylphosphonothioates, and three of six phosphorami-dates, one of which was the commercial herbicide DMPA. Neurotoxic activity varied both with the number of halogen substituents on the phenyl group, and with the identity of the 4-phenyl halogen. Neurotoxic activity also varied with the alkyl group involved in the P-C or P-N bond, and with the identity of the 0-alkyl group.