Cobalt induced changes in immune response and adenosine triphosphatase activities in rats
Titel:
Cobalt induced changes in immune response and adenosine triphosphatase activities in rats
Auteur:
Chetty, K. N. Rao, D.S.V. Subba Drummond, L. Desaiah, D.
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 14 (1979) nr. 5 pagina's 525-544
Jaar:
1979
Inhoud:
The immuno-biochemical effects of cobaltous chloride in rats receiving iron-sufficient and deficient diets were investigated. Rats receiving 100 ppm or more cobalt showed a significant reduction in thymus and body weights along with a marked decrease in hemoglobin, hematocrit, sheep agglutinins and plaque forming cells. These effects were more pronounced in rats receiving cobalt mixed with iron-deficient diet than those fed on iron-sufficient diet. The Na+-K+ and mitochondrial (Oligomycin-sensitive) Mg2+ATPase activities in brain and liver of rats fed with iron-deficient diets were decreased significantly. However, the ATPase activities in these tissues from rats fed with cobalt mixed with iron-sufficient diets were not altered.