Sequential participation of glutathione and sulph-hydryl (S) in reductive dechlorination of 2, 4-di-, and 2, 4, 5-trichloro phenacyl chlorides by soluble fraction (105,000 x g) of chicken liver homogenate.
Titel:
Sequential participation of glutathione and sulph-hydryl (S) in reductive dechlorination of 2, 4-di-, and 2, 4, 5-trichloro phenacyl chlorides by soluble fraction (105,000 x g) of chicken liver homogenate.
Auteur:
Akhtar, M. Humayoun
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 14 (1979) nr. 1 pagina's 53-71
Jaar:
1979
Inhoud:
The mode of reductive dechlorination of α-chloroacetophenones, 2,4-di-, and 2,4,5-trichloro phenacyl chlorides into respective acetophenone by soluble fraction (105,000 x g) from chicken liver homogenate has been investigated. The transformation involved the sequential participation of glutathione and a sulph-hydryl. The phenacyl chloride first reacted with glutathione to yield the phenacyl glutathione, which in turn, in the presence of a sulph-hydryl, was reduced enzymatically to produce the ketone, probably via a disulfide intermediate.
Tijdschrift beschrijving