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| Titel: |
Contributions to ecological chemistry CXIV fate of 2, 2'-dichlorobiphenyl-14C in rats upon long-term feeding |
| Auteur: |
Kamal, Mahmoud Weisgerber, Irene Klein, Werner Korte, Friedhelm |
| Verschenen in: |
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes |
| Paginering: | Jaargang 11 (1976) nr. 4 pagina's 271-287 |
| Jaar: |
1976 |
| Inhoud: |
Each of five male and five female rats was orally dosed with 49.2 μg 2,2'-dichlorobiphenyl- 14C daily for 42 days. After 36 days, the radioactivity in the body reached a plateau level, and male rats had excreted 84.5% of the applied radioactivity, females 87.9%; the residues in most organs were below 0.2 mg/kg. The daily excreted radioactivity after 50 days had decreased to 0.7% (males) and 0.5% (females) of the daily dose; the total excretion was then 86.2% (males) and 89.4% (females) of the total applied dose, and the organs contained <0.1 mg/kg. More than 90% of the radioactivity in the excreta was due to metabolites (one monomethoxy-, three monohydroxy-, three dihydroxy-, one trihydroxy-2,2'-dichlorobiphenyl, conjugates, and a dechlorinated derivative). |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 6 gevonden artikelen
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