The metabolism of lindane and its metabolites gamma-2, 3, 4, 5, 6-pentachlorocyclohexene, pentachlorobenzene, and pentachlorophenol in rats and the pathways of lindane metabolism
Titel:
The metabolism of lindane and its metabolites gamma-2, 3, 4, 5, 6-pentachlorocyclohexene, pentachlorobenzene, and pentachlorophenol in rats and the pathways of lindane metabolism
Auteur:
Engst, Rudolf Macholz, Rainer M. Kujawa, Manfred Lewerenz, Hans-Jochen Plass, Roland
Verschenen in:
Journal of environmental science and health. Part B, Pesticides, food contaminants, and agricultural wastes
Paginering:
Jaargang 11 (1976) nr. 2 pagina's 95-117
Jaar:
1976
Inhoud:
The metabolism of lindane and its metabolites, gamma-PCCH, PCB, and PCP, has been studied in rats. Urine, faeces, blood and important organs were analyzed for free metabolites and those bound as beta-glucuronides. TeCCOL was identified as a main metabolite by GC/MS and gamma-PCCH has been evaluated toxicologically. A degradation scheme, based on experimental results and comprising only one hypothetical metabolite is proposed and discussed.