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| Titel: |
Influence of several antidotal treatments on the distribution and excretion of strontium |
| Auteur: |
Llobet, Juan M. Colomina, M. Teresa Domingo, Jose L. Corbella, Jacinto |
| Verschenen in: |
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering |
| Paginering: | Jaargang 27 (1992) nr. 4 pagina's 1103-1114 |
| Jaar: |
1992-05 |
| Inhoud: |
Eleven chelating agents were examined to determine their effectiveness on the removal of strontium in mice following s.c. injection of strontium nitrate (1139 mg/kg). Chelators were administered i.p. at doses equal to one-fourth of their respective LD50. Kryptofix 222 and diethylenetriamine pentaacetic acid (DTPA) were the most effective agents in increasing the urinary excretion of strontium and reducing the concentrations of strontium in various tissues. In a second series of experiments, tartaric acid, 1, 4, 7, 10, 13, 16-hexaoxacyclooctadecane (18-crown-6), ethyIenglycol-bis(/?-amino-ethylether)-N,N'-tetraacetic acid (EGTA), DTPA and Kryptofix 222 were administered i.p. ten minutes after the s.c. injection of strontium nitrate (95 mg/kg). At these levels of strontium, none of the chelators significantly enhanced the excretion of strontium or lowered the strontium tissue concentrations. Because the chelators tested were ineffective in removing strontium from the body, further investigations should be conducted to identify other chelating agents and conditions of administration which may significantly enhance the removal of strontium. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 7 van 18 gevonden artikelen
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