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Details for article 2 of 9 found articles
| Title: |
Comparative evaluation of macrocyclic drugs and their linear counterparts in preventing nickel toxicity in mice |
| Author: |
Srivastava, Amita Katiyar, S. S. Behari, Jai Raj Srivastava, Sanjay K. Hasan, S. K. Srivastava, R. C. |
| Appeared in: |
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering |
| Paging: | Volume 24 (1989) nr. 1 pages 77-86 |
| Year: |
1989-01 |
| Contents: |
The efficacy of a few macrocyclic drugs, viz. 1,4,8,11-tetraaza-cyclo-tetradecane (cyclam); 5,7,7', 12,14,14'-hexamethyl-l, 4,8,11-tetraaza-cy'clo-tetra-decane (cyclam-S); 1,4,8,11-tetrahydroxyethyl-1,4,8,11 -tetraazacyclo-tetradecane (THEC) and 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetrade-cane (TMC) and their linear counterparts, viz. triethylene-tetramine (TETA) and NN'-bis-(2-aminoethyl)-l,3-propane diamine (TET) was examined for prevention of mortality and nickel uptake in the body organs of nickel poisoned mice (at the level of 250 μ mole/kg i.p. of NiCl2 i.e. LD90 or greater), when administered at various molar ratios of nickel vs. drug. Amongst the chelating drugs the most effective antidote was cyclam followed by cyclam-S, TETA, THEC, TMC and TET. All the chelating drugs with exception to THEC demonstrated higher survival rate and low nickel body burden with increase in the drug concentration. Test for significant difference between a pair of proportions at various Nirdrug ratios further revealed that cyclam yielded a significantly higher survival rate than the other chelating drugs studied. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 2 of 9 found articles
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