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| Titel: |
The effect of 3-methylcholanthrene-induced increases in ascorbic acid levels on tissue β-glucuronidase activity in rats |
| Auteur: |
Calabrese, Edward J. Barrett, Thomas J. Leonard, Denise A. Horton, Holly M. Kenyon, Elaina M. |
| Verschenen in: |
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering |
| Paginering: | Jaargang 23 (1988) nr. 1 pagina's 23-33 |
| Jaar: |
1988-01 |
| Inhoud: |
The Interrelationship between tissue ascorbic acid levels and tissue β-glucuronidase activity was examined in rats injected with 3-methylcholanthrene, an agent which induces ascorbic acid synthesis in rats. Six Fisher 344 rats were dosed intraperitoneally (IP) with 30 mg/kg of 3-methylcholanthrene. Ascorbic acid levels and β-glucuronidase (β-G) activity were determined for lung, liver and kidney tissues. In a follow-up study, rats were dosed for three consecutive days with 3-methylcholanthrene. Controls in both groups were dosed IP with Emulphor (EL-620). Animals were sacrificed one week after the final dosage and lung, liver and kidney tissues were examined. Significant increases in liver ascorbic acid levels were found in both phases of the study and significant increases in kidney ascorbic acid levels were found in the follow-up study; however, no significant inhibition of tissue β-G was found. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 9 van 9 gevonden artikelen
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