A study of organometallic compounds for the selection of candidates for carcinogen bioassay
Titel:
A study of organometallic compounds for the selection of candidates for carcinogen bioassay
Auteur:
Doeltz, M. K. Mackie, M. Rich, P. A. Lent, D. Sigman, C. C. Helmes, C. T.
Verschenen in:
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering
Paginering:
Jaargang 19 (1984) nr. 1 pagina's 27-65
Jaar:
1984-01
Inhoud:
The class of organometallic compounds was studied in order to nominate chemicals to the National Cancer Institute as candidates for carcinogen bioassay. A preliminary list of 1,815 candidate chemicals was developed for four major subclasses: (1) alkyl organometallics; (2) aryl organometallics, coordination compounds, and miscellaneous organometallics; (3) organosilicon compounds; and (4) organophosphorus compounds. Based on an evaluation of both the evidence Indicating possible suspicion of carcinogenic activity and evidence indicating potential human exposure, the following five nominations were made: chromium carbonyl, ferrocene, ferric ammonium ferrocyanide, triphenylantimony, and the representative organosilicons, octamethyltrisiloxane, and octamethylcyclotetrasiloxane.