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| Titel: |
An evaluation of the dorset sheep as a predictive animal model for the response of G-6-PD deficient human erythrocytes to a proposed systemic toxic ozone intermediate, methyl linoleate hydroperoxide |
| Auteur: |
Williams, Perry S. Calabrese, Edward J. Moore, Gary S. |
| Verschenen in: |
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering |
| Paginering: | Jaargang 18 (1983) nr. 1 pagina's 1-17 |
| Jaar: |
1983 |
| Inhoud: |
Erythrocytes of both G-6-PD deficient humans and Dorset sheep, an animal model with an erythrocyte G-6-PD deficiency, both responded in a dose-dependent manner to the oxidant stress of MLHP as measured by decreases in G-6-PD activity, increases in METHB levels and decreases in GSH. However, the human G-6-PD deficient erythrocytes were considerably more sensitive to the formation of METHB than the sheep erythrocytes while the reverse was the case for the GSH parameter. The results suggest a qualitative difference in the response of sheep erythrocytes and human G-6-PD deficient erythrocytes to MLHP that seriously questions the value of the sheep erythrocyte as a quantitatively accurate predictive model. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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