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Details for article 78 of 111 found articles
| Title: |
Synthesis of 2-Carboxy-Substituted Sphingosine Derivatives |
| Author: |
Singh, Narrinder P. Giannis, Athanassios Henk, Elfi Kolter, Thomas Sandhoff, Konrad Schmidt, Richard R. |
| Appeared in: |
Journal of carbohydrate chemistry |
| Paging: | Volume 9 (1990) nr. 5 pages 543-559 |
| Year: |
1990 |
| Contents: |
From the sphingosine biosynthesis pathway it is deduced that 2-carboxy-substituted sphinganine derivatives should be suitable inhibitors of sphingosine biosynthesis. For their synthesis enantioselective acylation and α-hydroxyalkylation of serine was performed via its optically pure 2-tert-butyl-oxazolidine derivatives 4A, B and ent-4A, known to undergo partial chirality transfer from serine to the 2- position of 4 and then to the 4-position. Thus, after acid hydrolysis compounds R-7Aa, -7Ab, -7Ac, -7Bb, S-7Aa, -7Ab, and 11 are provided highly stereoselectively. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 78 of 111 found articles
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