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Details van artikel 60 van 178 gevonden artikelen
| Titel: |
Effect of Degree of Sulfation on Anti-Hiv Activity of Synthetic (1→5)-α-D-Ribofuranan Sulfate |
| Auteur: |
Hatanaka, Kenichi Nakajima, Ikuko Yoshida, Takashi Uryu, Toshiyuki Yoshida, Osamu Yamamoto, Naoki Mimura, Toru Kaneko, Yutaro |
| Verschenen in: |
Journal of carbohydrate chemistry |
| Paginering: | Jaargang 10 (1991) nr. 4 pagina's 681-690 |
| Jaar: |
1991 |
| Inhoud: |
Stereoregular (1→5)-α-D-ribofuranan prepared by selective ring-opening polymerization of anhydro-ribose derivatives was sulfated with piperidine N-sulfonic acid to give ribofuranan sulfates (RFS) with various degrees of sulfation (DS). NMR analysis of RFS indicated a similar reactivity of two hydroxyl groups (2-OH and 3-OH). Anti-HIV effects of RFS were investigated by using MT-4 cells, i.e., an HTLV-I-carrying CD-4 positive cell line in vitro. RFS with higher DS showed remarkably higher anti-HIV activity. Anticoagulant activity of RFS was also investigated. RFS with a high DS interacted more selectively with virus protein rather than other proteins in the blood than RFS with a low DS. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 60 van 178 gevonden artikelen
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