Chiral Epoxides for Leukotriene Syntheses : A D-Xylose Approach
Titel:
Chiral Epoxides for Leukotriene Syntheses : A D-Xylose Approach
Auteur:
Pougny, J. R. Rollin, P.
Verschenen in:
Journal of carbohydrate chemistry
Paginering:
Jaargang 5 (1986) nr. 4 pagina's 701-704
Jaar:
1986-12-01
Inhoud:
Characterization of SRS-A, an important mediator of asthma and other hypersensitivity processes, was not achieved until 19791. It has been proposed that leukotriene A4 (LTA4) is the short-lived key biochemical intermediate which can be either converted to LTB4 by enzymatic hydration or to LTC4, a precursor to LTD4 and LTE4, by glutathine transfer2. Therefore, in order to mimic the biosynthetic pathway, LTA4 has been the prime synthetic target3. A survey of the various methods described in the literature clearly shows the pivotal status of the key-synthons, methyl 7-hydroxy-5, 6-epoxyheptanoates (e.g. 4 and 6).
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