Glycopolymers from Synthetic Fragments (Amides of α-d-Galacturonic Acid with Amino Acids) of Proteus O-Antigens
Titel:
Glycopolymers from Synthetic Fragments (Amides of α-d-Galacturonic Acid with Amino Acids) of Proteus O-Antigens
Auteur:
Chernyak, Anatoly Ya. Kononov, Leonid O. Kochetkov, Nikolay K.
Verschenen in:
Journal of carbohydrate chemistry
Paginering:
Jaargang 13 (1994) nr. 3 pagina's 383-396
Jaar:
1994-04-01
Inhoud:
Galacturonamides of amino acids (alanine, lysine, serine, and threonine), constituents of Proteus O-specific polysaccharides, have been synthesised. O-tert-Butyl and Nε-tert-butyloxycarbonyl protected amino acid tert-butyl esters were condensed with the 2-azidoethyl α-glycoside of d-galacturonic acid, prepared by Fischer glycosidation. Reduction of the azido group followed by N-acryloylation and deprotection gave the target monomers. By copolymerisation with acryl-amide, these were converted into glycopolymers potentially useful for defining epitopes in Proteus O-antigens.