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Details van artikel 7 van 252 gevonden artikelen
| Titel: |
A General Method for the Modification of the 9-Position of N-Acetyl-neuraminic Acid (NANA) and the Synthesis of Its 9-Fluoroanalogue |
| Auteur: |
Sharma, Moheswar Korytnyk, Walter |
| Verschenen in: |
Journal of carbohydrate chemistry |
| Paginering: | Jaargang 1 (1982) nr. 3 pagina's 311-315 |
| Jaar: |
1982-01-01 |
| Inhoud: |
Analogs of N-acetylneuraminic acid (1, NANA) are of considerable interest as potential modifiers of cell surface sialic acid. NANA is greatly responsible for the negative charge on cell surface, and plays an important role in cell-to-cell Interactions, immunogenic properties, and metastasis.1 Considerable difficulty has been encountered in the development of approaches for the modification of this molecule.2 The only fluorinated sialic acid which has been reported 1s N-acetyl-3-fluoro-neuraminic acid, a compound which was obtained in only 1% yield.3 A systematic approach to the introduction of protecting groups into NANA, a process which would make specific groups amenable for modification, has not been explored. In this communication we report a successful application of a protection-deprotection approach (Scheme 1) to the synthesis of N-acetyl-9-deoxy-9-fluoroneuraminic acid (7). |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 7 van 252 gevonden artikelen
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