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Details van artikel 46 van 252 gevonden artikelen
| Titel: |
Communication: A Facile Synthesis of a Glycoconjugate Cationic Polymer Carrying the 3,6-Branched α-D-Mannosyl Trisaccharide Cluster |
| Auteur: |
Tanaka, Hidehiko Nishida, Yoshihiro Kobayashi, Kazukiyo |
| Verschenen in: |
Journal of carbohydrate chemistry |
| Paginering: | Jaargang 19 (2000) nr. 3 pagina's 413-418 |
| Jaar: |
2000 |
| Inhoud: |
Receptor-mediated gene transfection1 has gained central interests since Wu and Wu2 demonstrated successful gene transfection into hepatocytes by using an asialoglycoprotein-poly(L-lysine) complex as a nonviral gene vector. Besides the hepatoma cells possessing galactose-specific receptor proteins, macrophages bearing mannose-specific receptors can also become a target of the gene transfection.3-5 Though partially mannosylated poly(L-lysine)3,4 and mannosylated avidin5 have been tested for this purpose, development of more effective vectors with higher cytoselectivity is required for gene therapies. As a part of our research efforts to develop and apply artificial glycoconjugate polymers carrying biologically active oligosaccharides,6-8 our interest has been directed to the potential utility of 3,6-branched α-D-mannoside for the receptor mediated gene transfer targeting macrophages. The 3,6-branched mannosyl trisaccharide is reported to be the much better ligand of mannose-specific binding proteins than mono- and linear oligomannosides.9 In this communication, we report a facile synthesis of a glycoconjugate cationic polymer carrying the 3,6-branched α-D-mannoside cluster10,11 and evaluate its binding affinity to a mannose-specific lectin, concanavalin A. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 46 van 252 gevonden artikelen
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