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| Titel: |
Synthetic Studies of the 5-Aminopentose 2-Sulfate Component of the Liposidomycins |
| Auteur: |
Kim, Kwan Soo Lim, Jee Woong Joo, Yung Hyup Kim, Kun Tai Cho, In Haeng Ahn, Yeong Hee |
| Verschenen in: |
Journal of carbohydrate chemistry |
| Paginering: | Jaargang 14 (1995) nr. 3 pagina's 439-443 |
| Jaar: |
1995-04-01 |
| Inhoud: |
The liposidomycins are a family of novel lipid-containing nucleoside antibiotics that were recently found in the culture filterate and mycelia of Streptomyces griseosporeus.1 These antibiotics inhibit formation of the lipid intermediate in bacterial peptidoglycan synthesis.1,2 The primary site of action of liposidomycin C was found to be phospho-N-acetylmuramylpentapeptide transferase from E. coli Y-10 in peptidoglycan synthesis.3 The structures of liposidomycins A, B, and C were proposed as 1, 2, and 3, respectively, on the basis of degradation and spectroscopic studies,2,4 but six stereogenic centers in the lipid and diazepinone moieties remain unassigned. The overall structure as well as the diazepinone and 5-aminopentose 2-sulfate components are very unique. The present work reports synthetic studies related to the 5-amino-5-deoxy-P-Driboside 2-sulfate part of the liposidomycins. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 216 van 252 gevonden artikelen
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