Details van artikel 183 van 252 gevonden artikelen
Synthesis of C-Glycosyl α-Glycines
Titel:
Synthesis of C-Glycosyl α-Glycines
Auteur:
Pochet, Sylvie Allard, Patrice Huynh-dinh, Tam Igolen, J.
Verschenen in:
Journal of carbohydrate chemistry
Paginering:
Jaargang 1 (1982) nr. 3 pagina's 277-288
Jaar:
1982-01-01
Inhoud:
A scheme of asymmetric synthesis of C-glycosyl α-glycines is described. Reductive hydrolysis of 2-deoxy-3,5-di-O-p-toluoyl-β D-erythropentofuranose 1-cyanide (4) in the presence of N,N-diphenylethylenediamine gave the imidazolidine 5, which was converted to 2,5-anhydro-3-deoxy-4,6-di-O-p-toluoyl-β-D-allose (3)by acid hydrolysis. The aldehyde (3), chiralamine, benzoic acid and t-butyl isocyanide four component condensation afforded in good yield two diastereomeric adducts (6a and 6b), which were separated by column chromatography and deblocked to furnish 2-deoxy-β-D-erythropentofuranosyl R and S-glycines (1a) and (1b).
Uitgever:
Taylor & Francis
Bronbestand:
Elektronische Wetenschappelijke Tijdschriften
Details van artikel 183 van 252 gevonden artikelen