Four new terpenoids from the roots of Ligularia narynensis
Title:
Four new terpenoids from the roots of Ligularia narynensis
Author:
Gao, Xue Xie, Wei-Dong Jia, Zhong-Jian
Appeared in:
Journal of Asian natural products research
Paging:
Volume 10 (2008) nr. 2 pages 185-192
Year:
2008-02
Contents:
Four new oplopane and guaiane type sesquiterpenoids (1-3), and a monoterpenoid (4) together with three known monoterpenoids (5-7), have been isolated from the roots of Ligularia narynensis. The structures of 1-4 were elucidated as 3β,4-diacetoxy-8α-(2-methylbutyryloxy)-9α-(4-methylsenecioyloxy)-11α,12-epoxyoplop-10 (14)-ene (1), 3β,4-diacetoxy-9α-(4-acetoxy-4-methylsenecioyloxy)-2β,8α-di (2-methylbutyryloxy)-11α,12-epoxyoplop-10 (14)-ene (2), 2α-hydroxy-1βH,7αH,10αH-guai-4,11 (12)-dien-3-one (3) and 1α,2β,3α,6α-tetrahydroxy-p-menthane (4) by spectroscopic methods. 1 and 2 were evaluated for their in vitro cytotoxic activity against cultured SMMC-7721 (human hepatoma), L02 (human hepatocyte), and HL-60 (human promyelocytic leukaemia) cell lines.