|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 42 van 111 gevonden artikelen
| Titel: |
Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus B3 myocarditis |
| Auteur: |
Zhang, Z. -C. Li, S. -J. Yang, Y. -Z. Chen, R. -Z. Ge, J. -B. Chen, H. -Z. |
| Verschenen in: |
Journal of Asian natural products research |
| Paginering: | Jaargang 9 (2007) nr. 2 pagina's 145-151 |
| Jaar: |
2007-03 |
| Inhoud: |
Astragaloside is the major component of Astragalus membranaceus, one of the Chinese medical herbs, and has several pharmacological actions on cardiovascular system, including positive inotropic, anti-arrhythmia and anti-oxidant activities. We have investigated the effect of astragaloside on cardiomyocyte apoptosis and expression of apoptosis-associated genes in mice with coxsackievirus B3 (CVB3)-induced myocarditis, the former of which has been detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end-labeling (TUNEL) assay and the latter determined by using a focused microarray. Results showed that cardiomyocyte apoptosis and expression of various apoptosis associated genes are inhibited after treatment with astragaloside. The anti-apoptotic activity of astragaloside may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 42 van 111 gevonden artikelen
| << vorige | volgende >> |