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Details for article 16 of 111 found articles
| Title: |
A new semisynthetic ocotillol-type saponin and resuscitation of haemorrhagic shock |
| Author: |
Liu, J. -P. Lu, D. Zhao, Y. Li, P. -Y. Li, X. |
| Appeared in: |
Journal of Asian natural products research |
| Paging: | Volume 9 (2007) nr. 2 pages 103-113 |
| Year: |
2007-03 |
| Contents: |
A new ocotillol-type saponin (PGQ) has been semisynthesised from 20(S)-ginsenoside Rg3 for the first time, in with a yield of 73%, by oxidation and cyclisation of the side-chain. Its structure was characterised by IR, HR-MS, 1H NMR, 13C NMR, 1H-1H COSY, DEPT, HMBC and HMQC spectroscopy as 3-O-[β-d-glucopyranosyl-(1-2)-β-d-glucopyranosyl]-dammar- 20S,24S-epoxy-3β,12β,25-triol (1). The saponin produced a beneficial effect on resuscitation of haemorrhagic shock as follows: first, it could significantly rise increased mean arterial pressure; second, it could increased blood oxygen content; third, it could markedly decreased serum lipoperoxidase and increased superoxide dismutase (SOD) activities. Thus, the saponin had the effect of an anti-haemorrhagic shock. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 16 of 111 found articles
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