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| Titel: |
Application of an innovative matrix solid-phase dispersion-solid-phase extraction-liquid chromatography-tandem mass spectrometry analytical methodology to the study of the metabolism of the estrogenic mycotoxin zearalenone in rainbow trout liver and muscular tissue |
| Auteur: |
Lagana, Aldo Faberi, Angelo Fago, Giovanna Marino, Aldo Pastorini, Elisabetta Samperi, Roberto |
| Verschenen in: |
International journal of environmental analytical chemistry |
| Paginering: | Jaargang 84 (2004) nr. 13 pagina's 1009-1016 |
| Jaar: |
2004-11-15 |
| Inhoud: |
The metabolic fate of the estrogenic mycotoxin zearalenone in rainbow trout is presently unknown. In this study, the tissue concentration of zearalenone and its principal metabolites (α-zearalenol and β-zearalenol) was determined. A known amount of zearalenone was administered as a single bolus to ten fish, and the biological tissue concentration was determined at various times following administration. The analytes were extracted from liver and muscular tissue using an on-line matrix solid-phase dispersion-solid-phase extraction sample preparation protocol, and their concentration determined by HPLC-Turboionspray-tandem mass spectrometry. The results showed that zearalenone is mainly metabolized into α-zearalenol in both liver and muscular tissues. The maximum concentrations of each analyte found in liver were 76.1, 211.2 and 63.7 ng/g respectively for zearalenone, α-zearalenol and β-zearalenol, while in muscular tissue they were 10.7, 8.2 and 6.5 ng/g. These values were reached after 2 h in liver tissue and 12 h in muscular tissue. Moreover the data obtained showed that the elimination rate in liver is quite fast since 48 h after the exposure less than 7% of the maximum concentration found is still present. In muscular tissue, however, about one-third of the maximum concentration found is still present after 48 h. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 20 gevonden artikelen
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