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| Titel: |
Application of Kinetic and Dynamic Data for Antihistamines to Risk Characterization in Sensitive Populations |
| Auteur: |
Skowronski, Gloria A. Abdel-Rahman, Mohamed S. Turkall, Rita M. |
| Verschenen in: |
Human and ecological risk assessment |
| Paginering: | Jaargang 8 (2002) nr. 4 pagina's 859-876 |
| Jaar: |
2002-10-01 |
| Inhoud: |
A major goal of risk assessment is to protect the health of individuals who may be more sensitive than the general population. This study compared human phar-macokinetic and pharmacodynamic data in sensitive groups (i.e., children, the elderly, diseased states, and poor metabolizers) versus young, healthy adults for the antihistamines cetirizine, fexofenadine, loratadine, azelastine, ebastine, chlorpheniramine, and diphenhydramine. The default components (3.16 each for kinetic and dynamic aspects) of the intraspecies uncertainty factor were adjusted with compound specific data for the antihistamines. The majority (16 of 18) of the composite factors (kinetics X dynamics) for the sensitive groups were less than 10. Children had the lowest composite factors for antihistamines, ranging from 1.1 to 6.3. Application of kinetic and dynamic data for antihistamines to the Renwick/International Programme on Chemical Safety (IPCS) scheme can aid in characterizing the extent of variability in sensitive populations, thereby reducing the uncertainty associated with the risk assessment of sensitive populations. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 24 van 222 gevonden artikelen
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