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Opportunities to improve quantitative risk assessment
Titel:
Opportunities to improve quantitative risk assessment
Auteur:
Sielken, Robert L. Stevenson, Donald E.
Verschenen in:
Human and ecological risk assessment
Paginering:
Jaargang 3 (1997) nr. 4 pagina's 479-489
Jaar:
1997-09
Inhoud:
Quantitative risk assessment should help risk managers evaluate a broad spectrum of risk management alternatives by meaningfully quantifying their costs and benefits. However, current assessments are primarily based on a single quantitative analysis using default assumptions and simplistic bounding procedures that were originally intended only as screening procedures and are not designed to identify the real magnitudes of costs and benefits. There are significant opportunities to improve the current methods of quantitative risk assessment through less reliance on default assumptions, greater use of available data and expert judgement, increased use of probabilistic techniques including distributions and trees, more informative exposure characterizations, more biologically-based dose metrics, more mechanistically-based dose-response models, reflecting biological feedback systems, incorporating interspecies differences in background transition rates from stage to stage in multistage processes, including the effects of age in dose metrics and dose-response models, including the time of any response in the characterization of risk, and greater use of human epidemiological data in dose-response modeling.
Uitgever:
Taylor & Francis
Bronbestand:
Elektronische Wetenschappelijke Tijdschriften
Details van artikel 145 van 222 gevonden artikelen
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