Pristine Fullerene C60: Different Water Soluble Forms—Different Mechanisms of Biological Action
Titel:
Pristine Fullerene C60: Different Water Soluble Forms—Different Mechanisms of Biological Action
Auteur:
Sirotkin, A. K. Zarubaev, V. V. Poznyiakova, L. N. Dumpis, M. A. Muravieva, T. D. Krisko, T. K. Belousova, I. M. Kiselev, O. I. Piotrovsky, L. B.
Verschenen in:
Fullerenes, nanotubes & carbon nanostructures
Paginering:
Jaargang 14 (2006) nr. 2-3 pagina's 327-333
Jaar:
2006-12-01
Inhoud:
Aqueous fullerene preparations, namely complex of C60 with polyvinylpyrrolidone (C60/PVP) and molecular-colloidal water solutions of C60 (FWS) exhibit virocidal activity due to different mechanisms: C60/PVP complexes act mainly on the lipid component of virus membranes, while the mechanism of virocidal action of FWS is mainly connected with the ability of fullerene to generate singlet oxygen under irradiation. In the first case, fullerene acts mainly as a membranotropic agent, whereas in the second case it acts mainly as a photosensitizer.