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Details van artikel 2 van 8 gevonden artikelen
| Titel: |
A new procedure for testing equivalence in comparative bioavailability and other clinical trials |
| Auteur: |
Anderson, Sharon Hauck, Walter W. |
| Verschenen in: |
Communications in statistics |
| Paginering: | Jaargang 12 (1983) nr. 23 pagina's 2663-2692 |
| Jaar: |
1983 |
| Inhoud: |
The problem of testing for equivalence in clinical trials is restated here in terms of the proper clinical hypotheses and a simple classical frequentist significance test based on the central t distribution is derived. This method is then shown to be more powerful than the methods based on usual (shortest) and symmetric confidence intervals. We begin by considering a noncentral t statistic and then consider three approximations to it. A simulation is used to compare actual test sizes to the nominal values in crossover and completely randomized designs. A central t approximation was the best. The power calculation is then shown to be based on a central t distribution, and a method is developed for obtaining the sample size required to obtain a specified power. For the approximations, a simulation compares actual powers to those obtained for the t distribution and confirms that the theoretical results are close to the actual powers. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 8 gevonden artikelen
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