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Details for article 5 of 18 found articles
| Title: |
EFFECT OF RED CELL RIGIDITY ON GAS TRANSPORT BY SHEARED FLOWING BLOOD†|
| Author: |
Mottaghy, K. Haest, C. W. M. Schleuter, H. J. |
| Appeared in: |
Chemical engineering communications |
| Paging: | Volume 15 (1982) nr. 1-4 pages 157-167 |
| Year: |
1982-04-01 |
| Contents: |
By means of a blood flowing model the dependence of oxygen uptake by red blood cells (RBC) on the deformation of the RBC was investigated. The model allows measurements of oxygen transfer in flowing sheared blood. Simultaneously secondary flows can be produced, which enhances oxygen transfer rate of whole blood considerably. The model is applied to analyse the effect of an artificial rigidification of RBC on oxygen uptake by the cells. A diminution of RBC deformations, obtained by an oxidation of membrane SH-groups, is shown to result in a decrease of O2-uptake by RBC. This decrease is assumed to be due to a reduction of intracellular convection, which diminishes intracellular mixing of haemoglobin. Glutardialdehyde treatment results in an even higher decrease of oxygen uptake. In this case the complete lack of deformations of the RBC and of orientation in shear flow, which is typical for native RBC and is maintained in diamide RBC, is proposed to be responsible for this greater loss of O2-uptake. A shift of the O2-saturation curves of RBC as a consequence of the chemical modifications is shown not to be responsible for the diamide and glutardialdehyde effects. |
| Publisher: |
Taylor & Francis |
| Source file: |
Elektronische Wetenschappelijke Tijdschriften |
Details for article 5 of 18 found articles
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