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| Titel: |
Light/dark-induced effects on behavioral rhythms in suprachiasmatic nucleus-lesioned rats irrespective of the presence of functional suprachiasmatic nucleus brain implants |
| Auteur: |
Boer, Gerard J. Griffioen, Henriëtte A. Duindam, Hans van der Woude, Tjitske P. Rietveld, Wop J. |
| Verschenen in: |
Biological rhythm research |
| Paginering: | Jaargang 24 (1993) nr. 2 pagina's 118-136 |
| Jaar: |
1993-05 |
| Inhoud: |
Suprachiasmatic nucleus (SCN)-lesioned rats which had received a fetal SCN graft were kept in constant red light for three months. After this period it was examined whether those rats that showed a recovered free-running circadian rhythm could be entrained to light/dark cycles. To this end, they were subjected to a 12 h light/12 h dark schedule, followed by a 12 h light shift and again to dark conditions. In addition, the same regime was imposed on SCN-grafted rats without recovered circadian rhythms and on sham-grafted animals with a lesion, which were studied as controls. The presence of an SCN graft was identified immunocytochemically by the presence of vasopressin, vasoactive intestinal polypeptide and somatostatin cells. Drinking, eating and wheel-running rhythms were found to synchronize to the light/dark cycles in all rats, not with standing the presence of an SCN graft was. A 12 h light shift was immediately followed by a shift in the three rhythms. Under final dark conditions, free-running patterns reappeared in rhythm-recovered animals, without any convincing evidence for entrainment of the rhythms in the pattern of transition. Behavioral rhythms in SCN-lesioned rats are apparently masked by 12 h light/dark schedules via other visual pathways than the direct projection from the retina to the SCN. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 8 gevonden artikelen
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