Influence du misonidazole sur la variation circadienne de la respiration cellulaire hepatique chez la souris
Titel:
Influence du misonidazole sur la variation circadienne de la respiration cellulaire hepatique chez la souris
Auteur:
Malmary-Nebot, M. -F. Casanovas, A. -M. Labat, C. Martin, B. Oustrin, J.
Verschenen in:
Biological rhythm research
Paginering:
Jaargang 14 (1983) nr. 2 pagina's 95-100
Jaar:
1983-06
Inhoud:
Misonidazole, a heterocyclic nitrocompound shown to act as hypoxic cell radiosensitizer, is supposed to inhibit cellular oxygen consumption in vitro, depending upon certain conditions such as MIS concentration, and cellular content of various substrates. The effect of intraperitoneal injection of MIS at doses of 0.5 mg/g body weight, at 8 different time-points during the 24-h cycle, on the oxygen utilization of hepatic cellular homogenates of female Balb/c mice was investigated. A statistically significant rhythmicity was detected by analysis of variance among the O2 uptake values of control homogenates, whereas this rhythmicity was altered by treatment with MIS: inhibition of O2 consumption appeared when MIS was injected at 18.00 h or at 21.00 h, coinciding in time with the acrophase of the physiological rhythm of control O2 uptake.