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| Titel: |
Circadian effects of amphetamine on mouse brain serotonin |
| Auteur: |
Charlton, C. G. Owasoyo, J. O. Walker, C. A. |
| Verschenen in: |
Biological rhythm research |
| Paginering: | Jaargang 13 (1982) nr. 3 pagina's 241-248 |
| Jaar: |
1982-10 |
| Inhoud: |
The circadian levels of serotonin (5-HT) in the cerebral cortex and midbrain of adult male mice adapted to an LD 12:12 cycle were determined in control animals and in animals treated with 10 mg/kg intraperitoneally of amphetamine sulfate at 03.00 h, 07.00 h, 15.00 h or 19.00 h. Results show that 5-HT levels of the cerebral cortex and midbrain were highest during the light phase of the cycle and lowest during the dark phase of the cycle. Amphetamine caused a biphasic effect on 5-HT level in both brain tissues, with a brief initial decrease followed generally by an increase in 5-HT level, without altering the circadian pattern of the biogenic amine in these brain tissues. Our data also demonstrates that amphetamine effect on 5-HT levels in the brain areas is more profound when the drug is administered at 03.00 h, middle of the dark phase, rather than during the light phase of the cycle. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 2 van 7 gevonden artikelen
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