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| Titel: |
Sea-Nine™ 211 (4,5-dichloro-2-(n-octyl)-3(2H)-isothiazolone) is a Potent Stimulator of Eicosanoid Biosynthesis in the Sea Squirt, Ciona intestinalis (L.) |
| Auteur: |
Knight, John Rowley, Andrew F. Clare, Anthony S. |
| Verschenen in: |
Biofouling |
| Paginering: | Jaargang 14 (1999) nr. 3 pagina's 213-217 |
| Jaar: |
1999-12 |
| Inhoud: |
The isothiazolone, Sea-Nine 211™, is a broad-spectrum antifoulant whose mechanism of action is poorly understood. In the light of recent reports that eicosa-noids may modulate invertebrate larval settlement, the present study examined the effect of Sea-Nine 211 on eicosanoid biosynthesis in the sea squirt, Ciona intestinalis. Using RP-HPLC and examination of peak absorption spectra, the tunic of this species was shown to produce a range of lipoxygenase products, including 8-HEPE, 12-HEPE, 8,15-diHEPE and 8,15-diHETE. Sea-Nine 211™ was similar in potency to the calcium ionophore, A 23187, in inducing biosynthesis of these eicosanoids, being maximally effective at 5-10 μM. While the effect of Sea-Nine 211 on C. intestinalis settlement has yet to be examined, it is suggested that this antifoulant may exert its action, at least in part, by modulating eicosanoid biosynthesis. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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