|
| << vorige | volgende >> |
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 5 van 12 gevonden artikelen
| Titel: | |
| Auteur: | |
| Verschenen in: |
Analytical letters |
| Paginering: | Jaargang 40 (2007) nr. 18 pagina's 3417-3429 |
| Jaar: |
2007-12 |
| Inhoud: |
A flow-injection spectrophotometric procedure was developed for determining N-acetylcysteine in pharmaceutical formulations. The sample was dissolved in deionized water and 400 µl of the solution was injected into a carrier stream of 1.0×10-2 mol l-1 sodium borate solution. The sample flowed through a column (70 mm length×2.0 mm i.d.) packed with Zn3(PO4)2 immobilized in a polymeric matrix of polyester resin and Zn(II) ions were released from the solid-phase reactor because of the formation of the Zn(II) (N-acetylcysteine)2 complex. The mixture merged with a stream of borate buffer solution (pH 9.0) containing 5.0×10-4 mol l-1 Alizarin red S and the Zn(II)Alizarin red complex formed was measured spectrophotometrically at 540 nm. The analytical curve was linear in the N-acetylcysteine concentration range from 3.0×10-5 to 1.5×10-4 mol l-1 (4.9 to 24.5 µg ml-1) with a detections limit of 8.0×10-6 mol l-1 (1.3 µg ml-1). The relative standard deviations (RSDs) were smaller than 0.5% (n=10) for solutions containing 5.0×10-5 mol l-1 (8.0 µg ml-1) and 8.0×10-5 mol l-1 (13.0 µg ml-1) of N-acetylcysteine, and the analytical frequency was 60 determinations per hour. A paired t-test showed that all results obtained for N-acetylcysteine in commercial formulations using the proposed flow-injection procedure and a comparative procedure agreed at the 95% confidence level. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 12 gevonden artikelen
| << vorige | volgende >> |