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Details van artikel 24 van 59 gevonden artikelen
| Titel: | |
| Auteur: | |
| Verschenen in: |
Analytical letters |
| Paginering: | Jaargang 40 (2007) nr. 17 pagina's 3232-3244 |
| Jaar: |
2007-01 |
| Inhoud: |
The synthesis of molecularly imprinted polymer (MIP) as a stationary phase of high-performance liquid chromatography (HPLC), for the efficient determination of sulfamethazine and sulfadimethoxine in tablets is reported. The polymers were prepared by a noncovalent method with sulfamethazine as the template, methacrylic acid as the functional monomer and ethylene glycoldimethacrylate as the cross-linker in the presence of chloroform as the solvent. The retention time of sulfamethazine and sulfadimethoxine were approximately 5.2±0.2 and 10.3±0.5 min, respectively. In order to compare the chromatographic data from the stationary phase, retention factor (k) and separation factors (α) were given. The values of α were 2.05∼2.17 showed that the MIP was able to recognize structurally subtle differences from the template molecule. The MIP was successfully applied to commercial tablet analysis and the result showed a good recovery with 99 and 98% for sulfamethazine and sulfadimethoxine. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 24 van 59 gevonden artikelen
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