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Details van artikel 174 van 305 gevonden artikelen
| Titel: |
Methadone treatment as a determinant of HIV risk reduction among injecting drug users: A nested case-control study |
| Auteur: |
Serpelloni, G. Carrieri, M. P. Rezza, G. Morganti, S. Gomma, M. Binkin, N. |
| Verschenen in: |
AIDS care |
| Paginering: | Jaargang 6 (1994) nr. 2 pagina's 215-220 |
| Jaar: |
1994-03-01 |
| Inhoud: |
In order to evaluate the protective effect of methadone treatment on HIV infection, we performed a nested case-control study on seroconverters (cases) who were part of a cohort of HIV-negative injecting drug users (IDUs) (controls). Controls were matched with cases by sex, age, duration of drug use and follow-up time. Information on methadone treatment in the year prior to seroconversion was collected using clinical registries. Univariate and multivariate conditional logistic regression were used to identify variables related to HIV-seroconversion. The study included 40 cases and 40 controls. Univariate analysis showed the following variables to be associated to HIV seroconversion: number of cycles of treatment, daily dose and time out of treatment. After performing multivariate analysis, daily dose remained protective with a linear effect noted even at low doses and time out of treatment was the most important risk factor. The risk increased 1.5 times for every 3 months spent out of treatment. Long-term methadone treatment protects against HIV infection. Its effect may be attributable to a reduction in the frequency of injecting drug use or to an increased knowledge of risk factors following counselling in drug centres. |
| Uitgever: |
Routledge |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 174 van 305 gevonden artikelen
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