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| Titel: |
Effect of lactation, pregnancy and somatotropin treatment on plasma IGF-1 concentrations, IGF-1 partition between binding protein groups and binding protein pattern in goats |
| Auteur: |
Riis, Poul Martin Nielsen, Mette Olaf Jacobsen, Jørgen |
| Verschenen in: |
Acta agriculturae Scandinavica. Section A, Animal science |
| Paginering: | Jaargang 48 (1998) nr. 1 pagina's 19-27 |
| Jaar: |
1998-02 |
| Inhoud: |
To elucidate the role of IGF-1 in the galactopoietic effect of somatotropin, the partition of plasma IGF-1 between groups of binding proteins (BP) was studied in goats at different stages of pregnancy, lactation and somatotropin treatment. By size-exclusion chromatography, total plasma IGF-1 was divided into a 150 kDa class and a 35 kDa class. Lactation was associated with marked reduction in plasma concentrations of IGF-1, specifically of the 150 kDa class. During lactation, BP3 concentrations were also low and BP3 circulated mainly in a “free”; or non-complex bound form. Somatotropin treatment changed IGF-1 concentration and distribution towards that seen in pregnancy. It is concluded that the change in distribution of IGF-1 and its binding protein at the start of lactaion means increased turnover of IGF-1 and probably increased availability of IGF-1 to mammary cells and other target tissues. The observed changes may be important aspects of the homeorhetic adaptation to lactation. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 5 van 8 gevonden artikelen
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