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| Titel: |
Possible Association of Growth Hormone Gene Polymorphism with Growth Hormone Release in Calves from Lines Selected for High and Low Milk Fat Yield |
| Auteur: |
Høj, Søeren Løvendahl, Peter Sejrsen, Kristen |
| Verschenen in: |
Acta agriculturae Scandinavica. Section A, Animal science |
| Paginering: | Jaargang 43 (1993) nr. 3 pagina's 129-135 |
| Jaar: |
1993-08-01 |
| Inhoud: |
Fifty-seven calves from two lines selected for high (n = 36) and low (n = 21) milk fat yield were typed for a known restriction fragment length polymorphism (RFLP) in the growth hormone (GH) gene. The genetic origin of the RFLP is an insertion (I)/deletion(D) in the 3'-region of the growth hormone gene. The calves were tested at 3-4 months of age and again at 9-10 months of age for plasma GH concentration before and following three GH release tests: fasting-refeeding (n = 57), arginine injection (n = 28) and thyrotropin-releasing hormone (TRH) injection (n = 24). The RFLP typing showed 36, 19 and 2 calves of the genotypes II, ID and DD at the I/D site, respectively. The frequency of the D-allele was higher in the high than in the low selection line (0.29 vs. 0.05, P <0.01). At 9-10 months of age the GH release following TRH injection was larger in calves with genotype II (35.9 ± 4.5 ng/ml) compared with calves with genotype ID (23.6 ± 3.8 ng/ml) (P <0.05), and the calves from the high line had a higher GH release after TRH injection (42.9 ± 5.5 ng/ml) compared to low-line calves (19.7 ± 3.4 ng/ml) (P <0.001). These results may indicate that the I/D site may affect or be a genetic marker for TRH-induced GH release in dairy calves. |
| Uitgever: |
Taylor & Francis |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 4 van 10 gevonden artikelen
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