The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding
Titel:
The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding
Auteur:
Cristofaro, Raimondo Carotti, Andrea Akhavan, Sepideh Palla, Roberta Peyvandi, Flora Altomare, Cosimo Mannucci, Pier Mannuccio