Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial
Titel:
Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial
Auteur:
Graham, Martin A. Senan, Suresh Robin Jr., Hernani Eckhardt, Nils Lendrem, Dennis Hincks, Jeffery Greenslade, Dennis Rampling, Roy Kaye, Stanley B. von Roemeling, Reinhard Workman, Paul