EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG
Titel:
EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG
Auteur:
Zhang, Yiqun Zhou, Lanlan Safran, Howard Borsuk, Robyn Lulla, Rishi Tapinos, Nikos Seyhan, Attila A. El-Deiry, Wafik S.