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| Titel: |
Postoperative follow up by dynamic light scattering: Detection of inflammatory molecular changes in the cornea, the vitreous and the lens |
| Auteur: |
Fankhauser II, Franz |
| Verschenen in: |
Technology & health care |
| Paginering: | Jaargang 15 (2007) nr. 4 pagina's 247-258 |
| Jaar: |
2007-08-01 |
| Inhoud: |
Objective: To detect post-op molecular changes and inflammatory processes by dynamic light scattering (DLS) in eye segments. To develop DLS parameters which are appropriate for the control of post-op course after ophthalmologic surgery. Methods, design: Three new DLS devices were tested in different post-op clinical settings such as pseudoexfoliation syndrome (PEX), cataract surgery and retinal surgery. In a second step DLS was used to detect molecular changes in the cornea of 6 patients after photo refractive keratectomy (PRK) and 16 patients after photo astigmatic refractive keratectomy (PARK). Results: In PEX-patients cataract surgery changed the DLS signals of the anterior chamber and the lens in a specific way compared to the pre-op situation. Cataract patients without PEX had more scattering particles post-op and retinal surgery modified the DLS signal of the vitreous. Furthermore it was shown that the length of the corneal scattering vector l correlated with the process of the corneal wound healing after PARK. One and three months after surgery the lengths of the scattering vectors had increased significantly but returned to pre-op values twelve months post-op. Discussion: The post-op transparency of eye segments such as the cornea, the vitreous and the anterior chamber depends primarily on the wound healing mechanisms. DLS seems to be a suitable method to control the corneal recovery after refractive surgery. Conclusions: The length of the scattering vector l correlates well with the wound healing after refractive surgery. However DLS-signals seem to contain information about the molecular composition of tissue too. Therefore further research is needed to refine the interpretation of the DLS signals. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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