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| Titel: |
The effects of delayed nerve repair on nerve regeneration in a silicone chamber model |
| Auteur: |
Danielsen, Nils Johansson, Bengt R. Dahlin, Lars B. |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 6 (2011) nr. 4 pagina's 317-322 |
| Jaar: |
2011-05-06 |
| Inhoud: |
The silicone chamber model for nerve regeneration is suitable to test the effects of exogenous agents or surgical manipulations on nerve regeneration. The total 16-day regeneration period used in this model makes it possible to analyze the effects of certain manipulations on the sequential advancement of the individual cellular components (circumferential perineurial-like cells, vessels, Schwann cells, axons, and myelin) into the chamber fibrin matrix. In the present study we compared the effects on cellular migration of a 7 day delayed chamber repair vs. chamber repair immediately after transection (control chambers) of the rat sciatic nerve. Regeneration was evaluated with light and electron microscopic techniques. Chambers implanted after a delay of 7 days had a statistically significant more advanced migration of vessels, Schwann cells, and axons from the proximal nerve stump and also a significantly increased vascular density as compared to control chambers. We conclude that a 7 day delayed nerve repair stimulates nerve regeneration in this specific silicone chamber model. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 1 van 1 gevonden artikelen