|
Tijdschrift beschrijving
Alle jaargangen van het bijbehorende tijdschrift
Alle afleveringen van het bijbehorende jaargang
Alle artikelen van de bijbehorende aflevering
Details van artikel 1 van 1 gevonden artikelen
| Titel: |
Reinstatement of motor deficits in recovered brain-injured animals: the role of cerebellar norepinephrine |
| Auteur: |
Boyeson, Michael G. Krobert, Kurt A. Scherer, Paul J. Grade, Charles M. |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 5 (2011) nr. 4 pagina's 283-290 |
| Jaar: |
2011-05-06 |
| Inhoud: |
Previous research has indicated that antagonists of locus ceruleus functioning, when administered during the acute phase of an injury, slow recovery of motor function following unilateral sensorimotor cortex injury. Following a recovery plateau in animals, it is possible to pharmacologically reinstate unilateral motor deficits in recovered animals with similar acting drugs given intraperitoneally. The present study was designed to localize the brain systems responsible for the reinstatement of the deficit after recovery from the cortical injury. The results indicate that maintaining functional recovery after injury is modulated by NE in the cerebellum contralateral to the injury, since microinfusions of phenoxybenzamine into this structure reinstate motor deficits. Additionally, removal of the noradrenergic projection to contralateral cerebellum through unilateral lesions of the locus ceruleus reinstate unilateral deficits more severely than the drug administration. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 1 van 1 gevonden artikelen