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| Titel: |
L-dopa does not add to the success of high-intensity language training in aphasia |
| Auteur: |
Breitenstein, Caterina Korsukewitz, Catharina Baumgärtner, Annette Flöel, Agnes Zwitserlood, Pienie Dobel, Christian Knecht, Stefan |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 33 (2015) nr. 2 pagina's 115-120 |
| Jaar: |
2015-01-07 |
| Inhoud: |
Purpose: L-dopa has been shown to improve outcome of moderate-intensity language training after stroke in acute aphasia. Given the critical role of training intensity we probed the effect of l-dopa in combination with high-intensity language training in chronic post-stroke aphasia. Methods: In this prospective, randomized, placebo-controlled, double-blind study, aphasia patients (>1 year post stroke) were administered 100/25 mg of l-dopa/carbidopa or placebo daily prior to four hours of language training for two weeks. Conditions were crossed-over after a wash-out period of 4 weeks. Results: An a-priori planned interim analysis (n = 10) showed that naming performance and verbal communication improved significantly and persistently for at least 6 months in every patient, but l-dopa had no incremental effect to intensive training. Conclusion: High-intensity language training in chronic aphasia may take learning to a ceiling that precludes additive benefits from l-dopa. Effects of l-dopa on post-stroke recovery during less intense treatment in chronic aphasia remain to be evaluated. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 8 van 12 gevonden artikelen
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