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| Titel: |
Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: An open-label randomized controlled study |
| Auteur: |
Pei, Yu-Cheng Fang, Tuan-Jen Hsin, Li-Jen Li, Hsueh-Yu Wong, Alice MK |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 33 (2015) nr. 2 pagina's 121-130 |
| Jaar: |
2015-01-07 |
| Inhoud: |
Purpose: To investigate the neurologic and functional effect of intracordal hyaluronate injections in acute unilateral vocal fold paralysis (UVFP) in a randomized controlled trial. Methods: In this open-label, randomized controlled study, 29 patients with UVFP were recruited within 6 months of their first outpatient visit and were randomized to receive either single hyaluronate injection (HI group) or conservative management (CM group). Quantitative laryngeal electromyography, videolaryngostroboscopy, UVFP-related quality of life (Voice Outcomes Survey, VOS), laboratory voice analysis, and health-related quality of life (SF-36) were evaluated at baseline, and at 1, 3 and 6 months post-injection in the HI group, and at baseline and 6 months in the CM group. Results: Improvements in most quality of life domains and other assessments were comparable between the HI and CM groups; however, the HI group had a greater improvement in the mental health domain of quality of life at the end of follow-up. Conclusions: Early hyaluronate injection cannot improve nerve regeneration but can result in long-lasting improvements in patients' psychosocial well-being, thus highlighting the importance of early intervention for patients with UVFP. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
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