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| Titel: |
Effect of a contralateral lesion on neurological recovery from stroke in rats |
| Auteur: |
Sun, Fen Xie, Lin Mao, XiaoOu Hill, Justin Greenberg, David A. Jin, Kunlin |
| Verschenen in: |
Restorative neurology and neuroscience |
| Paginering: | Jaargang 30 (2012) nr. 6 pagina's 491-495 |
| Jaar: |
2012-08-02 |
| Inhoud: |
Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1–28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke. |
| Uitgever: |
IOS Press |
| Bronbestand: |
Elektronische Wetenschappelijke Tijdschriften |
Details van artikel 3 van 8 gevonden artikelen
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